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Art-Sci by Sthitapranjya Pati

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Lines of Thought

The Yin and The Yang

The medial prefrontal cortex exerts top-down control over many key circuits involved in executive function, attention, cognition, and emotional behavior. Rat medial prefrontal cortex excitatory neurons expressing the chemogenetic transducer hM3Dq. A physiologically inert drug (Clozapine-N-Oxide or DREADD Agonist 21) can be used to make these neurons fire. 

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Sthitapranjya Pati

The balance between recurrent excitation and inhibition is key to canonical cortical computing. This image of the rat  medial prefrontal cortex shows that the activity marker c-Fos (Red) is present both in CamKIIa-positive excitatory neurons (Green) and inhibitory neurons (absence of green). Blue marks the nucleus of all cells.

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